Microgenderome

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social impairments, repetitive/stereotypic behavior, and deficits in communication. Several hypotheses have been postulated to explain neuronal mechanisms underlying ASD, namely glutamatergic(E)/GABAergic (I) imbalance, neuroinflammation, and gut-brain axis dysfunction. However, it is still controversial the contribution of each of them to the development of ASD. Neuropeptide Y (NPY) is considered a neuromodulator expressed in the central and peripheral nervous systems, playing critical roles in neuronal excitation/inhibition balance, neuroinflammation, and cognitive ability. Recently, it has been proposed that NPY are also involved in the regulation of social behavior and may contribute to ASD pathogenesis. However, the link between NPY and the gut-brain axis in ASD remains unclear. Thus, this project aims to understand if NPY impacts gut-brain crosstalk in ASD through gut modulation by L.reuteri administration.

gut-brain axis | autism spectrum disorder | microbiome | NPY | microbiome

2021-2024