SENSEing Autism

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterised by repetitive behaviours and difficulties in social interactions and communication. Additionally, aberrant sensory perceptions, obsessive-compulsive disorder and aggressive behaviours are common in this condition. Basal ganglia are crucial for sensory integration and motor control, mediating sensory input and behavioural output. We propose to investigate the link between abnormal sensory processing and repetitive and aggressive behaviours in ASD, by dissecting the role of basal ganglia circuits in sensory-motor integration, using the Neuroligin3R451C mouse model. We will induce sensory overload and 1) assess its effect on repetitive and aggressive behaviours, and 2) investigate underlying mechanisms by functional magnetic resonance imaging and in vivo electrophysiology. Furthermore, we will manipulate basal ganglia neural circuits via optogenetics to establish causal links between sensory stimulation, neural circuits and aberrant behaviour. By deepening the understanding of neurobiological mechanisms of ASD, this project will aid development of novel treatments for ASD-associated challenging behaviours.

autism spectrum disorder | basal ganglia | sensory processing | aggression | repetitive behaviors 

2024-2027