Unlocking Tryp in TSC

Tuberous sclerosis complex (TSC) is a neurological disorder characterized by brain abnormalities, such as cortical tubers, leading to severe epilepsy and autism spectrum disorder (ASD). While cortical lesions are a hallmark of TSC, the specific cortical alterations contributing to the symptomatology remain unknown. Tryptophan (Tryp) is an essential amino acid and a precursor for biologically important compounds, including the neurotransmitter serotonin (5-HT). Dietary Tryp intake influences 5-HT production, potentially impacting behavior and cognition, suggesting therapeutic benefits. Alterations in Tryp and 5-HT are implicated in several neurological disorders, including ASD and TSC. However, the specific role of Tryp in managing neurological function and autistic manifestations in TSC is not fully understood. This study investigated ASD-like behavior and its correlation with cortical neurophysiology alterations in the Tsc2 +/- mouse model. Additionally, we hypothesized that Tryp supplementation could address ASD manifestations and explored the impact of a Tryp-enriched diet. We aim to identify specific cortical alterations related to TSC-associated epilepsy and autistic features, providing insights for new therapeutic interventions.

tuberous sclerosis complex | tryptophan metabolism | serotonin pathway | epilepsy | autism spectrum disorder

2021-2024